The HOPE4MCI Alzheimer’s Trial is assessing the efficacy and safety of an investigational medication to determine if it can treat the symptoms associated with Mild Cognitive Impairment due to Alzheimer’s Disease (MCI due to AD) and control further progression leading to the onset of Alzheimer’s dementia.

Who is participating?

  • People whose symptoms are consistent with a diagnosis of aMCI
  • People who have a positive PET scan with florbetapir F18 injection (Amyvid™ beta-amyloid scan)

A PET scan, or positron emission tomography, is a test that uses a special type of camera and a tracer (a unique chemical) to look at organs in the body.

What happens during the study?

  • Study volunteers receive the investigational medication, a once-a-day oral tablet, or a placebo once-a-day oral tablet over a period of 18 months. The investigational medicine is an FDA-approved and commonly prescribed medication for epilepsy, but during this trial the dose is considerably lower

Study volunteers are assessed medically and by clinical/cognitive rating scales and receive a magnetic resonance imaging (MRI) scan that measures brain structure approximately every six months.

The HOPE4MCI study is underway. A full list of eligibility criteria is available at www.clinicaltrials.gov.

Learn more about clinical trials.

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